RecruitingEarly Phase 1NCT05700617
Cardiac Power Output in Cardiogenic Shock Patients
Myocardial Reserve in Advanced Heart Failure Patients
Sponsor
University of Chicago
Enrollment
5 participants
Start Date
Jul 6, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
Eligibility
Min Age: 18 Years
Inclusion Criteria9
- LVEF ≤ 40%
- Referred for RHC for:
- Evaluation for advanced heart failure therapies, including LVAD, OHT, temporary or long-term inotrope therapy, or counter-pulsation (temporary or long-term with NuPulse device OR
- Accurate assessment of invasive hemodynamics due to worsening clinical status, OR
- Assessment of myocardial recovery for consideration of LVAD or counter-pulsation (temporary IABP or long-term with NuPulse device) decommissioning or removal OR
- Assessment of cardiac function and valvular abnormalities prior to planned valvular surgery for MR or AI
- Estimated glomerular filtration rate (eGFR) ≥ 30 ml/min/1.73 m2
- Age ≥ 18 years-old
- Intent for admission based on RHC data
Exclusion Criteria5
- eGFR \< 30 ml/min/1.73 m2
- Severe, non-revascularized coronary artery disease
- Concurrent acute coronary syndrome
- Age \< 18 years-old
- History of significant ventricular arrhythmia without an ICD
Interventions
DRUG1:1 Randomization to receive milrinone
Randomized to receive either inotropic agent: milrinone or no agent
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05700617
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