Imaging the Pathogenesis of Cerebral Small Vessel Disease

This study is using advanced brain imaging techniques to better understand a condition called cerebral small vessel disease — where small blood vessels in the brain become damaged over time, increasing the risk of stroke and memory problems. The goal is to identify what causes the disease to progress. **You may be eligible if...** - You have had a stroke or show signs of stroke on brain imaging - You have at least one cardiovascular risk factor (high blood pressure, high cholesterol, or diabetes) - Brain MRI shows evidence of small vessel disease **You may NOT be eligible if...** - You are unable to complete three research MRI visits over about 15 months Talk to your doctor to see if this trial is right for you.