MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder

This study is testing whether MDMA (commonly known as ecstasy, used here in a controlled medical setting) combined with prolonged exposure therapy can help people who have both alcohol use disorder and PTSD — two conditions that often occur together and are difficult to treat separately. **You may be eligible if...** - You are 18 or older - You have been diagnosed with both PTSD and alcohol use disorder (at least moderate severity) for 6 months or more - You have previously tried treatment for either PTSD or alcohol use disorder - You have stable housing - You can identify someone (family, friend, or partner) who can support you after sessions - You are willing to taper off antidepressants or other conflicting medications under medical supervision **You may NOT be eligible if...** - You have a personal or family history of psychosis or bipolar disorder - You are pregnant or breastfeeding - You are currently going through alcohol withdrawal or have a history of severe withdrawal seizures - You cannot stop certain medications that interact with MDMA - You have a serious heart condition Talk to your doctor to see if this trial is right for you.