RecruitingNot ApplicableNCT05723679

Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

Targeting Breathing Limitations to Improve Functional Outcomes in Heart Failure With Preserved Ejection Fraction (HFpEF)

Sponsor

University of Texas Southwestern Medical Center

Enrollment

78 participants

Start Date

Jul 1, 2023

Study Type

INTERVENTIONAL

Conditions

Obesity Heart Failure With Preserved Ejection Fraction

Summary

The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.

Eligibility

Min Age: 55 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how breathing problems affect people with a type of heart failure called HFpEF — where the heart pumps normally but doesn't relax well. Researchers want to understand breathing limitations and find ways to improve how patients feel and function in daily life. **You may be eligible if...** - You have signs and symptoms of heart failure - Your heart pumps out more than 50% of its blood each beat (preserved ejection fraction) - You have evidence of abnormal heart relaxation (diastolic dysfunction), or you are a healthy volunteer for comparison **You may NOT be eligible if...** - You are under 55 years old - Your BMI is over 50 - You have atrial fibrillation (an irregular heartbeat) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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