Role of Coronary CTA on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population
Role of the Screening with Coronary Computed Tomography Angiography on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population: a Community-based, Prospective Randomised Trial
Zhang longjiang,MD
3,400 participants
Jun 28, 2023
INTERVENTIONAL
Conditions
Summary
The primary objective of this study is to determine whether coronary computed tomography angiography (CCTA) -based coronary heart disease(CHD) prevention strategy improves lipid-lowering treatment and cardiovascular risk factor control compared with traditional CHD prevention strategy, guided by a cardiovascular risk score.
Eligibility
Inclusion Criteria3
- Nanjing residents who have no plans to leave in the next 5 years
- Aged from 40 to 69 years
- Free of any known clinically cardiovascular disease Able to comprehend and sign an informed consent form
Exclusion Criteria7
- Serious liver dysfunction, defined as AST or ALT > 3 times the normal upper limit
- Chronic kidney disease (CKD) > stage 4, defined as eGFR < 30 ml/min/1.73 m2
- Prior CCTA or invasive coronary angiography within the last 5 years
- Any contraindications for CCTA
- Previous use of statin or non-statin lipid-lowering medication (such as ezetimibe, PCSK9 inhibitor and XueZhiKang)
- Life expectancy < 3 years
- Other reasons the researcher deems inappropriate to attend
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Intervention strategies according to CCTA results
Intervention strategies according to traditional cardiovascular risk stratification based on Chinese guidelines for lipid management (2023)
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05725096