Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach
Sex Hormone-specific Cardiovascular Risks in the Gut Microbiome-host Axis - A Longitudinal Cohort Study.
Charite University, Berlin, Germany
200 participants
Aug 29, 2022
OBSERVATIONAL
Conditions
Summary
The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors. It will follow 200 healthy transgender individuals for two years during their hormone replacement therapy (HRT) and analyze them for the possible emergence of cardiovascular risk factors in relation to changes in the gut microbiome, metabolome, and immunome. We would also like to phenotype cardiovascular disease.
Eligibility
Inclusion Criteria5
- Age 18-50
- Language requirements: German, English
- Previous gender hormone replacement therapy (HRT).
- Ability to give consent and written consent to participate.
- Health insurance (for clarification of incidental findings)
Exclusion Criteria2
- Diseases or functional disorders that, in the opinion of the study physician, preclude participation in the study.
- Incapacity or other circumstances that do not allow study participants to fully understand the nature, significance and scope of this study.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05334888