RecruitingNCT05734430

Genetics of Appendix Cancer Study

Genetics of Appendix Cancer: The GAP Study


Sponsor

Andreana Holowatyj, PhD, MSCI

Enrollment

700 participants

Start Date

Nov 11, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.


Eligibility

Min Age: 18 Years

Inclusion Criteria11

  • GAP Social
  • Known diagnosis of appendix cancer in the United States
  • Mentally and physically able to consent and participate in the study
  • GAP Vanderbilt
  • Known diagnosis of appendix cancer
  • Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study
  • Mentally and physically able to consent and participate in the study
  • GAP Parent
  • Biological parents (mother and/or father) of individuals actively participating in the GAP Study
  • Residing in the United States
  • Mentally and physically able to consent and participate in the study

Exclusion Criteria4

  • Women pregnant at the time of consent
  • Prisoners
  • Unable to provide informed consent
  • Unable to read, write, or complete questionnaires in English

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Interventions

GENETICGenetic profiling

Whole exome sequencing

OTHERRetrospective tissue procurement

Collection of archived fixed-formalin, paraffin-embedded (FFPE) primary appendix tumor tissues that were previously removed


Locations(1)

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, United States

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NCT05734430


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