RecruitingPhase 2Phase 3NCT05736744

Effect of Magnesium Sulphate Pretreatment in Pediatric Abdominal Surgery

Effect of Magnesium Sulphate Pretreatment on the Onset and Duration of Intense and Deep Neuromuscular Block of Rocuronium Versus Cis-Atracurium in Pediatric Abdominal Surgery

Sponsor

Assiut University

Enrollment

58 participants

Start Date

Jun 20, 2023

Study Type

INTERVENTIONAL

Conditions

Muscle Relaxation

Summary

In this study, the investigators will compare the effect of magnesium sulphate pretreatment on the onset and duration of intense and deep neuromuscular Block of rocuronium versus Cis-Atracurium and on the period of no response to nerve stimulation in children undergoing elective open abdominal surgeries.

Eligibility

Min Age: 2 YearsMax Age: 12 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Cis-Atracurium and a drug called MgSO4 for people with muscle relaxation. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 2 Years to 12 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMgSO4

The patients will be pretreated with magnesium sulphate infusion (30 mg kg-1, total volume 100 ml, infusion rate 5 ml min-1) 20 min. before induction of anesthesia.

DRUGCis-Atracurium

Cis-Atracurium will be administered at 0.1-0.15 mg/kg IV bolus for intubation and maintenance at a dose of 0.03 mg/kg iv on fixed intervals.