Effect of Magnesium Sulphate Pretreatment in Pediatric Abdominal Surgery
Effect of Magnesium Sulphate Pretreatment on the Onset and Duration of Intense and Deep Neuromuscular Block of Rocuronium Versus Cis-Atracurium in Pediatric Abdominal Surgery
Assiut University
58 participants
Jun 20, 2023
INTERVENTIONAL
Conditions
Summary
In this study, the investigators will compare the effect of magnesium sulphate pretreatment on the onset and duration of intense and deep neuromuscular Block of rocuronium versus Cis-Atracurium and on the period of no response to nerve stimulation in children undergoing elective open abdominal surgeries.
Eligibility
Inclusion Criteria4
- Age group 2-12 years old
- Both genders
- Children who will be scheduled to undergo elective laparoscopic surgeries.
- Patients with American Society of Anesthesiologist physical status classification of 1 or 2-
Exclusion Criteria7
- Patients who are beyond the selected age group.
- Patients on medications that interfered with muscle activity.
- Allergy to medications used in this study.
- Neuro-muscular diseases.
- Renal or hepatic impairment.
- Hypermagnesemia (\>2.5 mmol) or hypomagnesemia (\<1.7 mmol).
- Parental refusal to participate in the study
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Interventions
The patients will be pretreated with magnesium sulphate infusion (30 mg kg-1, total volume 100 ml, infusion rate 5 ml min-1) 20 min. before induction of anesthesia.
Cis-Atracurium will be administered at 0.1-0.15 mg/kg IV bolus for intubation and maintenance at a dose of 0.03 mg/kg iv on fixed intervals.
Locations(2)
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NCT05736744