Effect of MgSO4 Pretreatment on Muscle Relaxation
Effect of Magnesium Sulphate Pretreatment on Cis-Atracurium Induced Neuromuscular Block and Recovery Characteristics: A Randomized Controlled Trial.
Assiut University
100 participants
Jul 23, 2023
INTERVENTIONAL
Conditions
Summary
In this study, the effect of magnesium sulphate on the onset and duration of intense and moderate cis-atracurium induced neuromuscular blocking and on the period of no response to nerve stimulation will be evaluated in patients who will recieve magnesium sulphate (intervention group) and patients who will not recieve magnesium sulphate (comparator group).
Eligibility
Inclusion Criteria5
- Age group 18-60 years old
- Both genders
- Patients who will be scheduled to undergo elective otorhinolaryngological surgery.
- Patients with BMI between 18.5 and 24.9 Kg/m2.
- Patients with American Society of Anesthesiologist physical status classification of 1 or 2
Exclusion Criteria8
- Patients who are less than 18 years old or more than 60 years old.
- Patients on medications that interfered with muscle activity.
- Allergy to medications used in this study.
- Pregnancy or suspected pregnancy.
- Neuro-muscular diseases.
- Renal or hepatic impairment.
- Hypermagnesemia (\>2.5 mmol) or hypomagnesemia (\<1.7 mmol).
- Patients refusing to study
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Interventions
A magnesium sulphate infusion (60 mg kg-1, total volume 100 ml, infusion rate 10 ml min-1) will be administered to patients 10 min. before induction of anesthesia.
The patients will be pretreated with an intravenous 0.9% saline infusion (total volume 100 ml, infusion rate 10 ml min-1) 10 min before induction of anesthesia.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05757999