CBAS180 De-escalation Study

This study is testing a de-escalation approach to treating Barrett's esophagus with dysplasia (a condition where abnormal cells in the food pipe can progress to cancer) using a reduced-dose radiofrequency ablation (a technique that uses heat to destroy abnormal cells) protocol. **You may be eligible if...** - You are over 18 years old - You have flat Barrett's esophagus with low-grade or high-grade dysplasia confirmed by an expert pathologist, OR you have remaining dysplastic Barrett's esophagus after a prior endoscopic resection - You have not had any previous ablation (burning/destroying) treatment of the esophagus - You are healthy enough for endoscopic procedures **You may NOT be eligible if...** - You have a blockage in the esophagus that prevents passage of a scope - You have visible ulcers, masses, or nodules in the esophagus - You have a history of locally advanced esophageal cancer - You have had esophageal varices or previous esophageal surgery - You have active severe esophagitis Talk to your doctor to see if this trial is right for you.