Registry Study for Optimal Management of Liver Failure in the Chinese Population
Registry Study for Optimal Management of Liver Failure in the Chinese Population (RESOLVE-C)
First Affiliated Hospital Xi'an Jiaotong University
500 participants
Jan 6, 2023
OBSERVATIONAL
Conditions
Summary
Liver failure is the most severe form of liver damage caused by viral, alcoholic, drug-related and ischemia-reperfusion factors, often combined with extrahepatic organ damage, resulting in a high mortality rate. This study intends to construct a real-world case registry database of inpatients with liver failure based on an electronic clinical data collection system through a multicenter collaborative network to study the clinical characteristics, epidemiology of bacterial and fungal infections, the impact of sarcopenia on clinical prognosis, and optimization of treatment strategies such as antiviral and artificial liver in Chinese inpatients with liver failure. The cohort and experience generated from this study will be used as a support for a series of future studies to focus on clinical issues such as infection, end-stage liver disease combined with organ failure, and early warning of critically ill patients.
Eligibility
Inclusion Criteria4
- Patients with a diagnosis consistent with liver failure and pre-liver failure:
- Extreme weakness with significant gastrointestinal symptoms such as anorexia, vomiting and abdominal distention;
- Elevated alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) with progressive jaundice (TBil≥85.5 μmol/L);
- Bleeding tendency with PTA ≤ 60% or INR ≥ 1.5.
Exclusion Criteria1
- An event or complication that, in the judgment of the investigator, significantly affects the assessment of clinical status.
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Interventions
Acute onset, no history of underlying liver disease, liver failure characterized by degree Ⅱ or above hepatic encephalopathy developed within 2 weeks
The onset was acute, with no history of underlying liver disease, and clinical manifestations of liver failure appeared between 2 and 26 weeks
On the basis of chronic liver disease, the clinical manifestations of acute liver decompensation and liver failure appear in a short period
Locations(14)
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NCT05740696