RecruitingNot ApplicableNCT05745441

Dinner Time for Obesity and Prediabetes


Sponsor

Johns Hopkins University

Enrollment

32 participants

Start Date

Jul 5, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by which late eating harms metabolism is not fully understood but may be related to mis-timing of food intake in relation to the body's endogenous circadian rhythm. Conversely, harmonization of eating timing with endogenous circadian rhythm may optimize metabolic health. In this study the investigators will use gold-standard methods of characterizing circadian rhythm in humans to examine the metabolic impacts food timing relative to endogenous circadian rhythm.


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Early Dinner, a drug called Early Dinner tracer, and others for people with healthy, obesity, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 50 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALEarly Dinner

Dinner before DLMO

BEHAVIORALLate Dinner

Dinner after DLMO

DRUGEarly Dinner tracer

Stable isotope of oral \[2H31\] palmitate to measure fat oxidation, given with dinner before DLMO

DRUGLate Dinner tracer

Stable isotope of oral \[2H31\] palmitate to measure fat oxidation, given with dinner after DLMO


Locations(2)

Johns Hopkins Bayview Medical Center

Baltimore, Maryland, United States

National Institutes of Health Clinical Center

Bethesda, Maryland, United States

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NCT05745441


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