In-depth Characterization of Atriogenic Secondary Tricuspid Regurgitation Due to Atrial Fibrillation

This study is looking at a specific type of leaky heart valve — tricuspid regurgitation caused by atrial fibrillation (an irregular heart rhythm) — to better understand how this condition develops and progresses over time. This is an observational study using echocardiograms (heart ultrasound). **You may be eligible if...** - You are over 18 years old - You have persistent or permanent atrial fibrillation (a long-term irregular heart rhythm) - Your heart's main pumping function is normal (ejection fraction >50%) - You have mild or no disease in other heart valves (mitral, aortic) - You are able to come in for follow-up appointments **You may NOT be eligible if...** - You are pregnant - You have a pacemaker or implanted cardiac defibrillator (ICD) - You have previously had heart valve surgery or a catheter-based valve procedure - You have had a heart transplant - Your tricuspid valve leakage is caused by a structural defect (organic disease) rather than atrial fibrillation Talk to your doctor to see if this trial is right for you.