RecruitingNot ApplicableNCT05759780

OCT Vibrography for Biomechanical Properties of Tissues

A Study to Test the Potential of OCT Vibrography for Measuring Biomechanical Properties of Tissues

Sponsor

Massachusetts General Hospital

Enrollment

90 participants

Start Date

Aug 19, 2023

Study Type

INTERVENTIONAL

Conditions

Skin Diseases Cornea Gingival Diseases

Summary

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria5

Group 1:
• Subjects with healthy eyes (age 18 - 75, N = 50)
• Subjects with healthy skin (age 18 - 75, N = 10)
• Subjects with healthy gingiva (age 18 - 75, N = 10)
• Mild or moderate keratoconus subjects (age 18 - 40, N = 20)

Exclusion Criteria12

Subjects with history of eye diseases, and previous eye surgeries.
Subjects with diabetes, glaucoma family history
Subjects allergic to anesthetic eyedrop, especially proparacaine
Subjects with severe allergy
Subjects who have difficulty biting
Subjects who have recurrent corneal erosion
Group 2:
• Subjects with open cuts/sores on the skin, skin infection, or any contagious skin condition
Group 3:
• Subjects with open cuts/sores on the gingiva, gingiva infection, or any contagious gingiva condition
Group 4:
• Subjects with K-max above 60 diopters (Pentacam imaging) are excluded