Sarcoma Preoperative Radiation With Simultaneous INTegrated Boost (SPRINT)

This trial (called SPRINT) is evaluating a new radiation treatment approach for soft tissue sarcomas, where a boosted radiation dose is delivered to the most high-risk areas of the tumor at the same time as the regular dose — before surgery. This technique is called a simultaneous integrated boost. **You may be eligible if...** - You are 18 or older - You have been confirmed to have a soft tissue sarcoma (a rare cancer of connective tissues like fat, muscle, or nerve) - Your doctors plan to perform limb-sparing (conservative) surgery rather than amputation - Your overall health is reasonably good (performance status ≤1 by WHO or ≥70 by KPS scale) **You may NOT be eligible if...** - You have had radiation therapy to the same area before - Amputation is the only surgical option for you - You have a connective tissue disease (like scleroderma or lupus) that would worsen with radiation - You have a psychiatric condition preventing you from giving informed consent Talk to your doctor to see if this trial is right for you.