RecruitingNCT05765786

Diagnosing Variable Primary Aldosteronism.

Do we Miss a Common Subset of Primary Aldosteronism in Which There is Cyclical or Exaggerated Diurnal Variation in Secretion?

Sponsor

Queen Mary University of London

Enrollment

100 participants

Start Date

Feb 24, 2023

Study Type

OBSERVATIONAL

Conditions

Primary Aldosteronism High Blood Pressure

Summary

The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L.
Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing.
Patients with aldosterone results done at different times that indicate variability in production.
Willing to consent and participate in the study.