Primary Aldosteronism Clinical Trials

38 recruiting

Primary Aldosteronism Trials at a Glance

40 actively recruiting trials for primary aldosteronism are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Chongqing, Ürümqi, and Chengdu. Lead sponsors running primary aldosteronism studies include Qifu Li, Xinjiang Medical University, and Third Military Medical University.

Browse primary aldosteronism trials by phase

Treatments under study

About Primary Aldosteronism Clinical Trials

Looking for clinical trials for Primary Aldosteronism? There are currently 38 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Primary Aldosteronism trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Primary Aldosteronism clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 40 trials

Recruiting
Phase 2

A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism

Primary Aldosteronism
Shandong Suncadia Medicine Co., Ltd.60 enrolled2 locationsNCT07470983
Recruiting

Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion

Primary AldosteronismAdrenal InsufficiencyAutonomous Cortisol Secretion
Qifu Li521 enrolled1 locationNCT06955286
Recruiting

Steroids-Based Screening for Primary Aldosteronism

HypertensionPrimary Aldosteronism
Qifu Li406 enrolled1 locationNCT06941116
Recruiting
Not Applicable

REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study

Primary Aldosteronism
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal58 enrolled1 locationNCT06108427
Recruiting
Not Applicable

Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA

Primary Aldosteronism
Queen Mary University of London122 enrolled6 locationsNCT05405101
Recruiting
Not Applicable

68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)

Primary AldosteronismAutonomous Cortisol Secretion
Qifu Li178 enrolled1 locationNCT06833437
Recruiting

Prognosis of Primary Aldosteronism: A Prospective Cohort Study

Primary Aldosteronism
Xinjiang Medical University5,000 enrolled2 locationsNCT07378176
Recruiting

The Association Between Primary Aldosteronism and Cognitive Dysfunction

DementiaCognitive DysfunctionPrimary Aldosteronism+1 more
Xinjiang Medical University1,000 enrolled2 locationsNCT07304674
Recruiting
Not Applicable

Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE)

Primary Aldosteronism
Shumin Yang456 enrolled1 locationNCT07298954
Recruiting

The Effect of SAAE on Vascular Endothelial Function in PA Patients

Primary Aldosteronism
Second Affiliated Hospital of Nanchang University200 enrolled1 locationNCT05561361
Recruiting

Multi-omics Studies of Primary Aldosteronism

Primary Aldosteronism
Peking University First Hospital400 enrolled1 locationNCT07111351
Recruiting

Overnight Dexamethasone in Primary Aldosteronism Screening

HypertensionPrimary Aldosteronism
Medical University of Gdansk240 enrolled1 locationNCT06740838
Recruiting

Efficacy of Spironolactone Combined With Antihypertensive Drugs in Patients With Primary Aldosteronism

HypertensionPrimary Aldosteronism
Third Military Medical University350 enrolled1 locationNCT07137364
Recruiting
Not Applicable

PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism

Primary AldosteronismSecondary HypertensionAldosterone-Producing Adenoma+2 more
Seoul National University Hospital90 enrolled2 locationsNCT07027254
Recruiting

Diagnosing Variable Primary Aldosteronism.

Primary AldosteronismHigh Blood Pressure
Queen Mary University of London100 enrolled1 locationNCT05765786
Recruiting

Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat

HypertensionPrimary AldosteronismHypokalemia
Jens Titze80 enrolled4 locationsNCT06569589
Recruiting
Not Applicable

The Effect of SAAE on Ventricular Remodeling in PA Patients

Primary Aldosteronism
Second Affiliated Hospital of Nanchang University112 enrolled1 locationNCT05501080
Recruiting
Not Applicable

Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy

Primary AldosteronismSuprarenalectomySuper Selective Adrenal Artery Embolization
Xinjiang Medical University570 enrolled1 locationNCT06513585
Recruiting
Phase 1Phase 2

Application of Al18F-NOTA-Pentixafor PET/CT for Primary Aldosteronism

Primary AldosteronismPrimary Aldosteronism Due to Aldosterone Producing Adenoma
Peking Union Medical College Hospital150 enrolled1 locationNCT06773663
Recruiting
Phase 4

Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

HypertensionPrimary Aldosteronism
Brigham and Women's Hospital40 enrolled1 locationNCT05030545