RecruitingNCT05774561

Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring

Liquid Biopsies - a Possible Tool for Treatment Monitoring and Early Recurrence Detection in HPV-associated Diseases


Sponsor

The Institute of Molecular and Translational Medicine, Czech Republic

Enrollment

480 participants

Start Date

Jun 1, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

This trial will evaluate the possible benefits and the performance of liquid biopsies in HPV-associated cancer treatment monitoring. This study aims to find a combination of an adequately sensitive and specific sampling method and biomarkers for early risk stratification of disease recurrence.


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether liquid biopsies — blood tests that detect tiny fragments of viral DNA from HPV (human papillomavirus) — can be used to monitor treatment response and detect recurrence in people with HPV-related cancers such as cervical cancer and oropharyngeal (throat) cancer. **You may be eligible if...** - You are a woman diagnosed with cervical cancer or high-grade cervical lesions (HSIL) - You are a man or woman diagnosed with oropharyngeal cancer (throat cancer associated with HPV) - You are willing to sign an informed consent **You may NOT be eligible if...** - There are no specific exclusion criteria listed for this study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTArm A - Diagnostic test: HPV detection in liquid biopsies

Patients will be asked to perform self-collection of gargle lavage samples. Oropharyngeal swabs, breath condensate, and blood samples will be taken by trained clinicians.

DIAGNOSTIC_TESTArm B - Diagnostic test: HPV detection in liquid biopsies

Patients will be asked to perform cervicovaginal self-sampling using Evalyn Brush. Blood samples will be taken by trained clinicians.


Locations(1)

University Hospital Olomouc

Olomouc, Czechia

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NCT05774561


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