Oropharyngeal Cancer Clinical Trials

16 recruiting

Oropharyngeal Cancer Trials at a Glance

18 actively recruiting trials for oropharyngeal cancer are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Phase 2 with 6 trials, with the heaviest enrollment activity in Ann Arbor, Tampa, and Chicago. Lead sponsors running oropharyngeal cancer studies include Geisinger Clinic, Georgetown University, and Canadian Cancer Trials Group.

Browse oropharyngeal cancer trials by phase

Treatments under study

About Oropharyngeal Cancer Clinical Trials

Looking for clinical trials for Oropharyngeal Cancer? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Oropharyngeal Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Oropharyngeal Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 118 of 18 trials

Recruiting
Phase 2

A Study of Reduced Radiation Therapy and Standard-of-Care Chemotherapy in People With HPV-Positive Throat Cancer

Oropharyngeal CancerThroat CancerHuman Papilloma Virus+2 more
Memorial Sloan Kettering Cancer Center121 enrolled7 locationsNCT05491512
Recruiting
Phase 2

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Head and Neck CancerLaryngeal CancerOral Cavity Cancer+6 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins75 enrolled1 locationNCT07209189
Recruiting
Not Applicable

Treatment De-Escalation for Favorable Prognosis Human Papilloma Virus (HPV) or p16-Positive Oropharyngeal Cancer Receiving Definitive Radiotherapy

HPVTonsil CancerOropharyngeal Cancers+1 more
Georgetown University30 enrolled2 locationsNCT06902623
Recruiting
Phase 3

SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

Oropharyngeal Cancer
Canadian Cancer Trials Group510 enrolled36 locationsNCT05451004
Recruiting

Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring

Cervical CancerOropharyngeal CancerCervical Dysplasia+1 more
The Institute of Molecular and Translational Medicine, Czech Republic480 enrolled1 locationNCT05774561
Recruiting

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)

Oropharyngeal CancerHPV-Related Carcinoma
H. Lee Moffitt Cancer Center and Research Institute400 enrolled2 locationsNCT06305676
Recruiting
Phase 2

Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer

Oropharyngeal Cancer
University of Chicago30 enrolled1 locationNCT07290621
Recruiting
Phase 2

A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)

Oropharyngeal CancerSquamous Cell Carcinoma of the Oropharynx
University of Michigan Rogel Cancer Center150 enrolled1 locationNCT05894083
Recruiting

Integrated Cancer Repository for Cancer Research

Breast CancerLiver CancerEsophageal Cancer+47 more
University of Nebraska999,999 enrolled45 locationsNCT02012699
Recruiting
Phase 2

BALSTILIMAB on Viral Clearance in HPV+ Oropharyngeal Cancer Patients

Oropharyngeal CancerHPV
M.D. Anderson Cancer Center20 enrolled1 locationNCT05363709
Recruiting
Not Applicable

Enhancing Oral Cancer Awareness

PreventionOral CancerOral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer+3 more
Virginia Commonwealth University60 enrolled1 locationNCT06682494
Recruiting
Phase 2

Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer

CarcinomaOropharyngeal Cancer
Zachary Zumsteg50 enrolled4 locationsNCT06445114
Recruiting

Liposomal Bupivacaine and Transoral Robotic Surgery

Post Operative PainOropharyngeal CancerDysphagia, Oropharyngeal+1 more
Geisinger Clinic80 enrolled1 locationNCT05862792
Recruiting
Phase 1

Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

Oropharyngeal CancerSquamous Cell CarcinomaHuman Papilloma Virus+1 more
Ryan Carey30 enrolled1 locationNCT06747390
Recruiting
Phase 1

PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer

Head and Neck CancerOropharyngeal Cancer
University Medical Center Groningen17 enrolled1 locationNCT06446713
Recruiting
Not Applicable

Lymphatic Mapping Of Oropharyngeal Cancer

Oropharyngeal Cancer
University College, London150 enrolled2 locationsNCT04498221
Recruiting

Immune Biomarker Study for Head and Neck Cancer

Head and Neck CancerHypopharyngeal CancerLaryngeal Cancer+2 more
University of Erlangen-Nürnberg Medical School1,100 enrolled3 locationsNCT05375266
Recruiting
Phase 3

Assessment of Swallowing Function and Quality of Life in Oropharyngeal Cancer Patients Treated by Chemo-radiotherapy

Oropharyngeal Cancer
Jules Bordet Institute110 enrolled2 locationsNCT04019548