Glutamate Excitotoxicity and Its Role in Glioblastoma Biology
Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme
IRCCS San Raffaele
50 participants
Jun 1, 2020
OBSERVATIONAL
Conditions
Summary
Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasion
Eligibility
Inclusion Criteria2
- Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant).
- Patient able to provide informed consent.
Exclusion Criteria4
- Age \< 18 years
- Liver disease
- Severe anemia (Hb \<8mg/dl)
- Pregnancy
Interventions
Blood, CSF and brain tissue sampling of Glu and Glu regulatory proteins.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05775458