RecruitingNCT06185686

Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Assessing Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Sponsor

Washington University School of Medicine

Enrollment

16 participants

Start Date

Jul 10, 2024

Study Type

OBSERVATIONAL

Conditions

Brain Tumor, Primary

Summary

With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.

Eligibility

Min Age: 8 YearsMax Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study examines how proton radiation therapy affects brain activity and function in children and young adults with brain tumors. Using brain scans before and after treatment, researchers hope to understand changes in resting brain networks and identify ways to protect cognitive function. **You may be eligible if...** - You are between 8 and 21 years old - You have been newly diagnosed with a primary brain tumor of any type or location - Your treatment plan includes proton radiation therapy - Your life expectancy is at least one year - You (or your legal guardian) are willing to consent to participate **You may NOT be eligible if...** - You have a condition that makes MRI scanning unsafe (such as metal implants) - You cannot cooperate with MRI procedures even with sedation if needed - Your tumor is not being treated with proton radiation therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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