Postoperative Management for HNSCC Based on Pathological Response of Induction Chemotherapy and Immunotherapy

This study is looking at how to manage treatment after surgery for people with locally advanced head and neck squamous cell carcinoma (a type of cancer in the mouth, throat, or neck). Participants first receive chemotherapy combined with immunotherapy before surgery. After surgery, the treatment plan is tailored based on how well the cancer responded. The goal is to improve outcomes while reducing unnecessary treatment. **You may be eligible if:** - You are between 18 and 75 years old - You have been diagnosed with squamous cell carcinoma of the head and neck confirmed by biopsy - Your cancer is locally advanced (stage T3-T4 or has spread to lymph nodes) but has not spread to distant organs - You have already received induction chemotherapy plus immunotherapy, followed by surgery - Your general health is good (ECOG score 0–1) and you are expected to survive at least 6 months **You may NOT be eligible if:** - You have a history of other cancers (except early-stage skin cancer or cervical carcinoma in situ) - You received other anti-cancer treatments for this cancer before the induction therapy - You have had previous radiation to the head or neck - You are on high-dose corticosteroids or immunosuppressants - You have serious heart, brain, or other major health conditions Talk to your doctor to see if this trial is right for you.