Role of New High Resolution Ultrasonographic Modalities for Diagnosis of Fetal Nervous System Anomalies
Woman's Health University Hospital, Egypt
150 participants
Sep 30, 2024
OBSERVATIONAL
Conditions
Summary
The fetal CNS screening examination during the mid-trimester scan in low-risk pregnancies should include evaluation of the fetal head and spine, using transabdominal sonography. Evaluation of two axial planes allows visualization of the relevant cerebral structures to assess the anatomic integrity of the fetal brain.These planes are commonly referred to as the transventricular and transcerebellar planes. A third plane, the so-called transthalamic plane, is frequently added, mostly for the purpose of biometry. Structures that should be noted in the routine examination include the lateral ventricles, the cerebellum, the cisterna magna, and the cavum septi pellucidi (CSP). Head shape and brain texture should also be noted on these views.
Eligibility
Inclusion Criteria7
- Suspicion of CNS or spinal malformation at routine screening ultrasound
- Suspicion of CNS or spinal malformation at nuchal translucency scan
- Family history of inheritable CNS spinal malformations
- Previous pregnancy complicated by fetal brain or spinal malformation
- Fetus with congenital heart disease
- Monochorionic twins
- Suspected congenital intrauterine infection Exposure to teratogens known to affect neurogenesis
Exclusion Criteria1
- Low risk pregnancy
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Interventions
High-resolution ultrasonography to detect fetal CNS anomalies
Locations(1)
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NCT05778279