RecruitingNot ApplicableNCT04286516
Brain Connections for Arm Movement After Stroke
Brain Areas That Control Reaching Movements After Stroke: Task-relevant Connectivity and Movement-synchronized Brain Stimulation
Sponsor
VA Office of Research and Development
Enrollment
76 participants
Start Date
Jan 10, 2020
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
Eligibility
Min Age: 45 YearsMax Age: 90 Years
Inclusion Criteria11
- Be 45-90 years of age
- Have adequate language and neurocognitive function to participate in training and testing
- Be medically stable to participate in the study
- Be English speaking
- Be 45-90 years of age
- Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
- Stroke onset at least 6 months before enrollment
- Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
- Present with mild to moderate arm dysfunction
- Be medically stable to participate in the study
- Be English speaking
Exclusion Criteria9
- (for both groups)
- Unable to give informed consent
- Have a serious complicating medical illness that would preclude participation
- Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
- Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
- Unable to comply with requirements of the study
- Enrollment in another greater-than-minimal risk study
- Presence of medical condition or implant that prevents safe administration of TMS or MRI
- Pregnancy
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Interventions
DEVICETranscranial Magnetic Stimulation
Paired pulse transcranial magnetic stimulation
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04286516
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