Central Nervous System Diseases Clinical Trials

30 recruiting

Central Nervous System Diseases Trials at a Glance

31 actively recruiting trials for central nervous system diseases are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Not Applicable with 16 trials, with the heaviest enrollment activity in Pittsburgh, Brisbane, and Asyut. Lead sponsors running central nervous system diseases studies include Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Kessler Foundation, and Woman's Health University Hospital, Egypt.

Browse central nervous system diseases trials by phase

Treatments under study

About Central Nervous System Diseases Clinical Trials

Looking for clinical trials for Central Nervous System Diseases? There are currently 30 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Central Nervous System Diseases trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Central Nervous System Diseases clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 31 trials

Recruiting
Phase 2

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Central Nervous System DiseasesBrain CancerGlioblastoma Multiforme (GBM)+4 more
Black Diamond Therapeutics, Inc.162 enrolled4 locationsNCT07326566
Recruiting
Phase 1

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

NeoplasmsNeoplasms by SiteBrain Diseases+30 more
M.D. Anderson Cancer Center24 enrolled3 locationsNCT03911388
Recruiting
Phase 1Phase 2

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Breast NeoplasmsBreast DiseasesNeoplasms+5 more
Stemline Therapeutics, Inc.73 enrolled86 locationsNCT05386108
Recruiting
Phase 3

A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting
Not Applicable

Mixed Reality and Virtual Reality Technology With Mirror Therapy for Stroke Rehabilitation

Central Nervous System DiseasesStrokeCerebrovascular Disorders
Chang Gung Memorial Hospital45 enrolled1 locationNCT05903235
Recruiting
Not Applicable

Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application

Brain DiseasesCentral Nervous System DiseasesDepression+2 more
Centre Hospitalier Charles Perrens, Bordeaux200 enrolled1 locationNCT03678194
Recruiting
Not Applicable

Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity

Brain DiseasesCentral Nervous System DiseasesParkinson Disease+7 more
University Hospital, Bonn130 enrolled1 locationNCT07324330
Recruiting
Not Applicable

Gravity Stent-Retriever System For Reperfusion Of Large Vessel Occlusion Stroke Trial

Cardiovascular DiseasesBrain DiseasesCentral Nervous System Diseases+5 more
Gravity Medical Technology, INC100 enrolled11 locationsNCT06249776
Recruiting
Not Applicable

Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Upper Limb Recovery in Patients With Stroke

Brain DiseasesCentral Nervous System DiseasesStroke+2 more
King Saud University100 enrolled1 locationNCT07288385
Recruiting

Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation

Brain DiseasesCentral Nervous System DiseasesAtrial Fibrillation+11 more
Insel Gruppe AG, University Hospital Bern500 enrolled1 locationNCT06954610
Recruiting
Not Applicable

Clinical Evaluation of EEG Device for the Triage of Stroke Patients in the Ambulance

Cardiovascular DiseasesBrain DiseasesCentral Nervous System Diseases+5 more
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)275 enrolled1 locationNCT06871969
Recruiting
Not Applicable

Video Call Assisted Assessment of Acute Stroke

Brain DiseasesCentral Nervous System DiseasesStroke+3 more
University of Southern Denmark512 enrolled1 locationNCT06570681
Recruiting

PRecisiOn Medicine In StrokE: Evolution of Plasma Brain-Derived Tau in Acute Stroke

Brain DiseasesCentral Nervous System DiseasesStroke, Ischemic+5 more
Ludwig-Maximilians - University of Munich100 enrolled1 locationNCT06121336
Recruiting
Not Applicable

Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

Cardiovascular DiseasesCentral Nervous System DiseasesBlood Pressure+7 more
Kessler Foundation12 enrolled1 locationNCT05731986
Recruiting
Not Applicable

The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)

Cardiovascular DiseasesCentral Nervous System DiseasesBlood Pressure+6 more
Kessler Foundation5 enrolled1 locationNCT05725499
Recruiting

The Correlation of Intracranial Artery Calcification and Outcomes of Mechanical Thrombectomy

Brain DiseasesCentral Nervous System DiseasesStroke+6 more
Zhujiang Hospital434 enrolled1 locationNCT06418698
Recruiting
Phase 2Phase 3

Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke

Central Nervous System DiseasesCerebrovascular DisordersIschemic Stroke, Acute+1 more
University of Melbourne462 enrolled13 locationsNCT05892510
Recruiting
Not Applicable

Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

Cardiovascular DiseasesCentral Nervous System DiseasesStroke+2 more
Jorge Gonzalez-Martinez10 enrolled1 locationNCT06303869
Recruiting
Not Applicable

Brain Connections for Arm Movement After Stroke

Cardiovascular DiseasesCentral Nervous System DiseasesStroke+2 more
VA Office of Research and Development76 enrolled1 locationNCT04286516
Recruiting
Not Applicable

Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands

Brain DiseasesCentral Nervous System DiseasesParkinson Disease+8 more
Radboud University Medical Center110 enrolled1 locationNCT06193252