RecruitingNCT05782556

Freiburg TIPS Registry

Transjugular Intrahepatic Portosystemic Shunt (TIPS) for the Treatment of Portal Hypertension: an Observational Study

Sponsor

University Hospital Freiburg

Enrollment

2,000 participants

Start Date

Jan 1, 2023

Study Type

OBSERVATIONAL

Conditions

Liver Cirrhosis Portal Vein Thrombosis Portal Hypertension Non-Cirrhotic Portal Hypertension Budd Chiari Syndrome Portal Systemic Shunt

Summary

Patients with clinically significant portal hypertension allocated to implantation of a transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Medicine II of the University Medical Center Freiburg, Germany will be offered to participate in this prospective observational trial. Clinical and laboratory as well as outcome parameters will be assessed before and within the first 12 months after TIPS implantation following a regular follow-up schedule with clinical visits at the University Medical Center Freiburg. During follow-up visits, serum/plasma samples and peripheral blood mononuclear cells (PBMC) are collected and stored in a associated biobank.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This is a registry study at Freiburg University Hospital collecting data on patients who undergo a procedure called TIPS (transjugular intrahepatic portosystemic shunt). TIPS is a procedure used to reduce high blood pressure in the veins of the liver, which can occur in people with liver cirrhosis or other liver conditions. The registry tracks long-term outcomes to improve future care. **You may be eligible if:** - You are a patient who has been recommended to receive a TIPS procedure for high portal blood pressure caused by liver cirrhosis or another liver condition - You are willing to sign an informed consent form **You may NOT be eligible if:** - You withdraw your consent to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEImplantation of a transjugular intrahepatic portosystemic shunt (TIPS)

For TIPS implantation, a transjugular approach is used in all patients and a puncture needle was advanced into a hepatic vein. Puncture of the portal vein is performed using ultrasound guidance followed by portography after successful puncture of the portal vein. Further, the parenchymal tract isdilated and the stent graft is placed. Before and after TIPS implantation, portal venous and central venous pressures are measured to calculate the porto-systemic pressure gradient