Portal Hypertension Clinical Trials

39 recruiting

Portal Hypertension Trials at a Glance

51 actively recruiting trials for portal hypertension are listed on ClinicalTrialsFinder across 6 cities in 20 countries. The largest study group is Not Applicable with 16 trials, with the heaviest enrollment activity in Shenyang, Shanghai, and Guangzhou. Lead sponsors running portal hypertension studies include Chinese University of Hong Kong, Shanghai Zhongshan Hospital, and University Hospital Freiburg.

Browse portal hypertension trials by phase

Treatments under study

About Portal Hypertension Clinical Trials

Looking for clinical trials for Portal Hypertension? There are currently 39 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Portal Hypertension trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Portal Hypertension clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 51 trials

Recruiting

Natural History of Noncirrhotic Portal Hypertension

Cystic FibrosisTurner SyndromeImmunologic Deficiency Syndrome+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)400 enrolled1 locationNCT02417740
Recruiting
Not Applicable

Early TIPS in Patients With Liver Cirrhosis and Ascites

Liver CirrhosisPortal HypertensionAscites Hepatic
University Hospital Freiburg134 enrolled1 locationNCT06576934
Recruiting

Freiburg TIPS Registry

Liver CirrhosisPortal Vein ThrombosisPortal Hypertension+3 more
University Hospital Freiburg2,000 enrolled1 locationNCT05782556
Recruiting
Not Applicable

Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver Transplantation

Liver TransplantationPortal Hypertension
Istanbul Medipol University Hospital50 enrolled1 locationNCT07304466
Recruiting

Cera™ Vascular Plug System Post-Market Clinical Follow-Up

Arteriovenous FistulaAneurysmPortal Hypertension+3 more
Lifetech Scientific (Shenzhen) Co., Ltd.132 enrolled9 locationsNCT06099015
Recruiting

Exploration of Systemic and Portal Hemostasis in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Placement

Liver CirrhosisPortal Hypertension
Assistance Publique - Hôpitaux de Paris45 enrolled1 locationNCT07439939
Recruiting
Phase 4

Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis

CirrhosisAscitesPortal Vein Thrombosis+3 more
Asian Institute Of Medical Sciences220 enrolled1 locationNCT07521332
Recruiting
Phase 1Phase 2

EUS Guided Portal-systemic Pressure Gradient Measurement

CirrhosisPortal Hypertension
Chinese University of Hong Kong30 enrolled1 locationNCT04633356
Recruiting

Indicators Affecting PVT Recanalization

CirrhosisPortal Hypertension Related to CirrhosisPortal Vein Thrombosis+1 more
Shanghai Zhongshan Hospital1,500 enrolled1 locationNCT07473375
Recruiting
Not Applicable

Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)

CirrhosisPortal HypertensionNon-Cirrhotic Portal Hypertension+3 more
Military University Hospital, Prague40 enrolled2 locationsNCT07424963
Recruiting

Construction of a Portal Hypertension Biobank

Portal HypertensionVariceal Bleeding
Shanghai Zhongshan Hospital1,000 enrolled1 locationNCT07419724
Recruiting

3D-MRE for Assessing Cirrhosis, Advanced Chronic Liver Disease and Portal Hypertension

Cirrhosis, LiverAdvanced Chronic Liver DiseasePortal Hypertension
Shengjing Hospital150 enrolled1 locationNCT05475015
Recruiting

3D-MRE and 2D-MRE for Assessing Cirrhosis and Portal Hypertension

CirrhosisLiver Portal Hypertension
Shengjing Hospital100 enrolled1 locationNCT06205992
Recruiting
Not Applicable

Effect of Handgrip Strength on Portal Vein Hemodynamics in Patients With Liver Cirrhosis

Liver CirrhosisPortal Hypertension
Shanxi Provincial People's Hospital120 enrolled2 locationsNCT07116096
Recruiting
Phase 4

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

Portal Hypertension Related to CirrhosisLiver CirrhosesTIPS+1 more
The Cleveland Clinic70 enrolled1 locationNCT07058155
Recruiting
Not Applicable

Effectiveness and Safety of TIPS Stent Graft in the Treatment of Cirrhosis and Complications of Portal Hypertension

Portal Hypertension Related to CirrhosisVariceal BleedingAscites Hepatic
C. R. Bard166 enrolled1 locationNCT06669806
Recruiting

A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver Cirrhosis

MRIUltrasoundHepatocellular Carcinoma (HCC)+3 more
Mattias Ekstedt600 enrolled1 locationNCT07291141
Recruiting
Not Applicable

Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension

Portal Hypertension
Mayo Clinic60 enrolled3 locationsNCT06797193
Recruiting
Not Applicable

TIPS With or Without BCAA

SarcopeniaCirrhosisPortal Hypertension Related to Cirrhosis+2 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology164 enrolled1 locationNCT07281846
Recruiting

2D-shear Wave Spleen Elastography in Clinically Significant Portal Hypertension and High-risk Varices

Portal Hypertension Related to CirrhosisEsophageal Varices
Fondazione Policlinico Universitario Agostino Gemelli IRCCS450 enrolled1 locationNCT07122622