RecruitingNCT05783804

Plaque Reversal With Early, Aggressive Lipid Lowering Therapy

Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

60 participants

Start Date

Jul 7, 2022

Study Type

OBSERVATIONAL

Conditions

Coronary Artery Disease Progression

Summary

This study evaluates whether plaques in young patients with familial hypercholesterolemia (aged below 50 years) are susceptible to significant plaque regression with early, intensive lipid lowering therapy.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria3

Diagnosed with heterozygous familial hypercholesterolemia
Adult between 18 and 50 years old
LDL cholesterol levels above 100 mg/dl (\>2.6 mmol/L) at inclusion

Exclusion Criteria5

Renal insufficiency, defined as eGFR \< 30 ml/min
History of atherosclerotic cardiovascular events
Atrial fibrillation
Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.

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