The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

This is an observational study (not testing a new treatment) looking at survival rates and quality of life after salvage surgery in people with head and neck squamous cell cancer (a type of throat or mouth cancer) that has come back or wasn't fully cleared after radiation treatment. **You may be eligible if...** - You are over 18 - You previously had squamous cell carcinoma of the head and neck treated with radiation (with or without chemotherapy) - Your cancer has come back locally, in the neck lymph nodes, or a new primary cancer has appeared in the same area - You are willing to provide a biological sample for molecular analysis (optional sub-study) **You may NOT be eligible if...** - Your cancer is nasopharyngeal, skin-based, thyroid, salivary gland, or not a squamous cell type - Your cancer has spread to distant organs (e.g., lungs, liver) Talk to your doctor to see if this trial is right for you.