The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE
The Prevalence, Risk Factors and Optimal Biopsy Protocol of Barrett's Esophagus in Taiwan - A Prospective Randomized Study
E-DA Hospital
165 participants
Mar 13, 2023
INTERVENTIONAL
Conditions
Summary
Detections of goblet cells and dysplasia are crucial for diagnosis and determining the surveillance program of Barrett's esophagus (BE). However, the optimal biopsy numbers and their yield rates of intestinal metaplasia (IM) and dysplasia are still uncertain, especially in Asia. The aim of this study was to determine the optimal biopsy protocol of BE.
Eligibility
Inclusion Criteria1
- Adults with columnar-lined esophagus
Exclusion Criteria6
- A prior history of endoscopic treatment for Barrett's Esophagus
- A prior history of upper gastrointestinal malignancy
- A prior history of total or subtotal gastrectomy
- Esophageal varices noted during the procedure
- Uncontrolled coagulopathy
- Taking antiplatelet drug or anticoagulant
Interventions
To do one biopsy at the proximal part of the longest columnar-lined esophagus.
To do three biopsy at the proximal, middle and distal part of the longest columnar-lined esophagus.
To do 4-quadrant biopsy every 1-2 cm at the esophagogastric junction. Seattle protocol has been considered as the gold standard biopsy protocol for patients with suspected Barrett's Esophagus.
The participants will receive meticulous endoscopic examination with narrow-band imaging.
Locations(1)
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NCT05818072