Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

This study tests whether semaglutide — a medication used for weight loss and type 2 diabetes — can help restore regular menstrual cycles and ovulation in young women and girls with polycystic ovary syndrome (PCOS) who are overweight or obese and currently not ovulating regularly. PCOS is a hormonal condition that can affect periods, fertility, and metabolism. **You may be eligible if...** - You are female, aged 12–35 - You are sedentary (less than 2 hours of moderate exercise per week) - You have PCOS with irregular periods (oligomenorrhea) - If under 18: your BMI is at or above the 95th percentile for your age - If 18–35: your BMI is 30 or higher, OR 27 or higher with a weight-related health problem like high blood pressure **You may NOT be eligible if...** - You have previously used semaglutide or similar GLP-1 medications - You have a history of pancreatitis or thyroid cancer - You are pregnant or breastfeeding - You have serious kidney or liver disease Talk to your doctor to see if this trial is right for you.