RecruitingPhase 2NCT07400588

Aleniglipron Phase 2 in Type 2 Diabetes Mellitus

A Phase 2, Randomized, Double-blind, Placebo-controlled, Study of the Safety and Tolerability of Aleniglipron in Adult Participants With Type 2 Diabetes Mellitus Living With Obesity or Overweight


Sponsor

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Enrollment

50 participants

Start Date

Dec 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to assess the safety and tolerability of aleniglipron at doses up to 240 mg once daily (QD) in participants with T2DM who are living with obesity (body mass index \[BMI\] ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2).


Eligibility

Min Age: 18 YearsMax Age: 79 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new medication called aleniglipron to see if it can help control blood sugar in people with type 2 diabetes. Researchers want to find out how well it works and whether it is safe. **You may be eligible if...** - You have been diagnosed with type 2 diabetes for at least 6 months - Your HbA1c (a blood sugar average test) is between 6.5% and 10% - Your body mass index (BMI) is 27 or higher **You may NOT be eligible if...** - You are currently being treated for diabetic eye disease (retinopathy or macular edema) - You take medications that interfere with blood sugar levels - Your weight has changed by more than 11 pounds in the last 3 months - You have had or are planning weight-loss surgery - You have had a stomach or intestinal procedure for obesity in the last 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGAleniglipron

Drug aleniglipron administered orally

DRUGPlacebo

Drug placebo administered orally


Locations(17)

Research Site

Anniston, Alabama, United States

Research Site

Lake Forest, California, United States

Research Site

Lomita, California, United States

Research Site

Hazelwood, Missouri, United States

Research Site

Columbus, Ohio, United States

Research Site

Moncks Corner, South Carolina, United States

Research Site

Chattanooga, Tennessee, United States

Research Site

Knoxville, Tennessee, United States

Research Site

Austin, Texas, United States

Research Site

Austin, Texas, United States

Research Site

DeSoto, Texas, United States

Research Site

Houston, Texas, United States

Research Site

Mesquite, Texas, United States

Research Site

San Antonio, Texas, United States

Research Site

San Antonio, Texas, United States

Research Site

San Antonio, Texas, United States

Research Site

Tomball, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07400588


Related Trials