RecruitingNCT05820074

Investigating Neural Biomarkers for Gait in Parkinson's Patients

Sponsor

Swiss Federal Institute of Technology

Enrollment

60 participants

Start Date

Apr 13, 2023

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease Gait Disorders, Neurologic

Summary

This observational study's main goal is to learn more about the neural mechanisms during movement in Parkinson's disease. Furthermore, it aims to inspire personalised treatment options. Participants will undergo a protocol that involves walking and gait-related motor tasks, such as seated stepping. During the protocol, brain activity will be recorded.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates brain signals (neural biomarkers) that are linked to walking difficulties in people with Parkinson's disease, particularly those who experience postural instability or freezing of gait. Researchers will use brain and body sensors to record activity while participants walk, with the aim of improving understanding and future treatment of movement problems in Parkinson's. **You may be eligible if...** - You have been diagnosed with non-tremor-dominant Parkinson's disease - You have postural instability or walking difficulties as part of your condition - You are 18 or older and have provided written consent - OR you are a healthy person with no neurological or movement disorders willing to serve as a comparison participant **You may NOT be eligible if...** - You have had surgery involving a brain stimulator (DBS) already implanted - You have epilepsy or an active psychiatric disorder - You have other significant neurological, orthopedic, or joint conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTNeural Activity Recording

Neural Activity is measured using EEG in all groups. Additionally, in Parkinson's patients, local-field-potentials from deep brain stimulation electrodes are recorded.

DIAGNOSTIC_TESTMovement Parameter Recording

Gait-related movement parameters are non-invasively recorded using motion capture, accelerometers and electromyography.

OTHERNeuromodulation

Neural signals are recorded with the electrodes of the deep brain stimulation device. Parkinson's patients are asked to modulate their neural activity by observing the streamed neural activity and applying mental strategies.