RecruitingNCT05820074

Investigating Neural Biomarkers for Gait in Parkinson's Patients

Sponsor

Swiss Federal Institute of Technology

Enrollment

60 participants

Start Date

Apr 13, 2023

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease Gait Disorders, Neurologic

Summary

This observational study's main goal is to learn more about the neural mechanisms during movement in Parkinson's disease. Furthermore, it aims to inspire personalised treatment options. Participants will undergo a protocol that involves walking and gait-related motor tasks, such as seated stepping. During the protocol, brain activity will be recorded.

Eligibility

Min Age: 18 Years

Inclusion Criteria12

All participants
must have given informed consent as documented by signature
agree to comply with the study procedures
Healthy control group
no neurological, orthopedic, or rheumatologic disease history
no identified sensory impairment.
no epilepsy and self-diagnosed acute or chronic psychiatric disorders
Parkinson's Patients
non-tremor dominant idiopathic PD patients
presence of postural instability (UPDRS \>1 for postural instability \[17\]), gait disturbance, and absence of other causes of reduced balance
Implanted with Percept™ PC neurostimulator
Able to be in the stimulation OFF

Exclusion Criteria3

Relevant cognitive impairment, with a score on Montréal Cognitive Assessment (MoCA) \< 20
History of physical or neurological condition that interferes with study procedures
Social and/or personal circumstances interfering with the ability to come to the session

Interventions

DIAGNOSTIC_TESTNeural Activity Recording

Neural Activity is measured using EEG in all groups. Additionally, in Parkinson's patients, local-field-potentials from deep brain stimulation electrodes are recorded.

DIAGNOSTIC_TESTMovement Parameter Recording

Gait-related movement parameters are non-invasively recorded using motion capture, accelerometers and electromyography.

OTHERNeuromodulation

Neural signals are recorded with the electrodes of the deep brain stimulation device. Parkinson's patients are asked to modulate their neural activity by observing the streamed neural activity and applying mental strategies.