Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes

This phase 1 study tests TLC-6740, a new experimental drug, for the first time in humans. The study first assesses safety in healthy volunteers, then tests it in people with obesity with or without diabetes. The drug is being developed as a potential new treatment for obesity and diabetes-related conditions. **You may be eligible if...** - You are a healthy non-smoker between 18 and 55 years old with a BMI of 19–35 (for healthy volunteer part) - OR you are between 18 and 70 with a BMI of 30 or higher and have obesity with or without type 2 diabetes (for the obesity/diabetes part) - Your kidney function, liver enzymes, and blood tests are within acceptable ranges **You may NOT be eligible if...** - You are a smoker or have recently quit - You have significant heart, liver, or kidney disease - You have type 1 diabetes - You are pregnant or breastfeeding - You have taken other investigational drugs recently Talk to your doctor to see if this trial is right for you.