Anti-Inflammatory Challenge in Schizophrenia

This study tests whether giving an anti-inflammatory drug can help reduce motivation problems (a symptom called amotivation or negative symptoms) in people with schizophrenia or schizoaffective disorder who have elevated levels of a blood marker of inflammation (CRP). Some research suggests that brain inflammation may contribute to the flat affect and low motivation seen in schizophrenia. **You may be eligible if...** - You are between 18 and 45 years old - You have a diagnosis of schizophrenia or schizoaffective disorder - You have significant motivational problems (score above 17 on a standard scale) - Your blood CRP level is elevated (above 3 mg/L), suggesting active inflammation **You may NOT be eligible if...** - You have very high CRP levels suggesting another active medical illness - You have a condition that prevents the use of the anti-inflammatory drug - You have had a recent serious infection or surgery - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.