Long-term Efficacy of Pramipexole in Anhedonic Depression

This study is looking at the long-term effects of a medication called pramipexole in people with depression who experience a loss of ability to feel pleasure (called anhedonia). It is a follow-on study for people who took part in an earlier short-term clinical trial of this drug. **You may be eligible if...** - You previously participated in the related short-term pramipexole clinical trial (EudraCT# 2022-001563-26) - If you received the placebo in the earlier trial, you still have significant anhedonia symptoms (difficulty feeling pleasure) - You have given informed consent to participate **You may NOT be eligible if...** - You are pregnant, breastfeeding, or planning to become pregnant - You are assessed as being at high risk of suicide - You have active substance abuse within the last 6 months - You currently have psychosis, emotionally unstable personality disorder, or a current ADHD diagnosis with hyperactivity - You have been recently diagnosed with intellectual disability or dementia - You have severe kidney or cardiovascular disease - You recently started psychotherapy (within 6 weeks) or are planning to Talk to your doctor to see if this trial is right for you.