RecruitingPhase 3NCT05825235

Long-term Efficacy of Pramipexole in Anhedonic Depression

Long-term Efficacy and Tolerability of add-on Pramipexole for Anhedonic Depression - an Open Label Follow-up Study

Sponsor

Region Skane

Enrollment

80 participants

Start Date

Apr 21, 2023

Study Type

INTERVENTIONAL

Conditions

Depression Anhedonia

Summary

The purpose of the study is to assess the long-term efficacy and safety of add-on pramipexole for treatment of patients with anhedonic depression.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria5

Previous participation in RCT testing the short-term efficacy of pramipexole vs placebo (EudraCT# 2022-001563-26).
Study participants randomized to pramipexole in the RCT who wish to continue with their treatment can enrol in the study.
The research subject has given informed consent to participate in the study.
Additional inclusion criterion for patients receiving placebo during the RCT
Anhedonia symptoms: 3 or 4 points on ≥ 3 items of the Snaith-Hamilton Pleasure Scale (SHAPS-C). This has been adopted in previous studies as a definition of "clinically significant anhedonia".

Exclusion Criteria15

Pregnancy, breastfeeding or planned pregnancy (if female).
High suicide risk according to the overall clinical assessment of the research physician.
Ongoing substance abuse (within 6 months).
Diagnosis of current psychosis.
Known diagnosis of Emotionally Unstable Personality Disorder.
Treatment under LPT.
History of impulse control disorder (including current binge-eating disorder) or a current ADHD diagnosis with hyperactivity.
Diagnosis of intellectual disability, dementia, or other circumstance that makes it difficult to understand the meaning of participating in the trial and give informed consent.
Diagnosis of renal failure or severe cardiovascular disease (specifically symptomatic heart failure NYHA Class II). Blood samples from RCT are sufficient to rule this out.
Recently started psychotherapy (within 6 weeks) or planning to start such treatment during participation in the trial.
Ongoing ECT, ketamine or rTMS treatment, excluding maintenance ECT, ketamine or rTMS (Maintenance treatment is defined as the use of ECT/ketamine/rTMS for a period exceeding 3 months after a series of ECT/ketamine/rTMS treatment in order to prevent the onset of a new episode).
Other medical conditions or other concomitant drug treatment (see section 14.5) which, in the opinion of the investigators, may affect the evaluability of the trial or conditions that increase trial risk. For example, Parkinson's disease, hepatic insufficiency, ongoing cancer not in remission for more than one year, gastric bypass surgery that affects the absorption of extended release tablets.
Known or suspected allergy to any active substance or excipient in the medicinal product included in the trial.
Participation in other treatment studies.
Other reason, as assessed by the investigator, that prevents the research subject's participation, such as the risk that the research subject is unable to complete the trial (non-compliance).