RecruitingPhase 4NCT05826327

Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression in Parturients

Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression and Maternal and Neonatal Outcomes in Parturients With Prenatal Depression

Sponsor

Women's Hospital School Of Medicine Zhejiang University

Enrollment

364 participants

Start Date

May 1, 2023

Study Type

INTERVENTIONAL

Conditions

Postpartum Depression

Summary

Postpartum depression is a common psychological abnormality during the puerperium, which seriously affects maternal and neonatal health. Esketamine, the S-enantiomer of ketamine, is twice as potent as ketamine and can be safely used for cesarean section and labor analgesia. However, it is not clear whether esketamine used for epidural labor analgesia can significantly reduce the incidence of postpartum depression. This study intends to explore the incidence of maternal prenatal depression and to investigate the effect of esketamine for epidural labor analgesia on postpartum depression and maternal and neonatal outcomes in parturients with prenatal depression through a multi-center, large-scale and high-quality clinical trail, in order to provide a clinical basis and theoretical basis for the application of esketamine used for epidural labor analgesia in postpartum depression and further reduce the incidence of postpartum depression, promote maternal and infant health, and ensure maternal and infant safety .

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether adding a small dose of esketamine (a type of anesthetic related to ketamine) to epidural pain relief during labor can reduce the chances of developing postpartum depression (low mood and depression after giving birth). **You may be eligible if...** - You are pregnant at full term - You have signs of low mood before delivery (Edinburgh Postnatal Depression Scale score of 10 or higher), but have not been formally diagnosed with depression by a psychiatrist - You have elected to have epidural analgesia for labor pain relief - You have provided written informed consent **You may NOT be eligible if...** - You have a pre-existing psychiatric diagnosis such as depression, schizophrenia, or a communication disorder - You have serious pregnancy complications such as severe preeclampsia, HELLP syndrome, or placenta previa - You have uncontrolled high blood pressure, severe heart disease, or hyperthyroidism - You have contraindications to ketamine-type medications - You refuse to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.