Microvascular Cardiac Allograft Vasculopathy Trial
Morphological and Functional Phenotype of Isolated Microvascular Cardiac Allograft Vasculopathy in Heart Transplant Recipients
German Heart Institute
50 participants
Oct 1, 2022
OBSERVATIONAL
Conditions
Summary
The aim of the mCAV study is a comprehensive characterization of the genetic, morphological and functional phenotype of isolated microvascular graft vasculopathy (mCAV) after orthotopic heart transplantation (OHT). The utilized methods include dynamic echocardiography, magnetic resonance imaging, invasive microvascular resistance measurements, histology, cellular calcium-signaling and magnetocardiography as well as molecular genetic expression analysis (miRNA based).
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Echocardiography with afterload change
Stress-MRI
Magnetocardiography
Histological analysis
miRNA sequencing
cardiomyocyte calcium signaling
Index of microvascular resistance measurement
Angiography derived post-processing index if microvascular resistance
Locations(1)
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NCT05826444