RecruitingNCT05835570

Integrin αvβ6-targeted PET in Malignant Tumors

A Single-arm, Open-label, Single-center Clinical Study to the Evaluation of Integrin αvβ6-targeted Positron Emission Tomography (PET) for Malignant Tumors


Sponsor

Zhongnan Hospital

Enrollment

200 participants

Start Date

Jan 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Malignant tumors are a significant health threat with high incidence and mortality rates, and molecular imaging is crucial for early diagnosis, staging, prognosis evaluation, and therapeutic efficacy assessment. 18F-FDG PET imaging is widely used, but has limitations. Integrin αvβ6 is a promising target for tumor-targeted imaging, as it is only expressed in cancerous or reconstructed epithelial cells. A new PET probe, 68Ga-Trivehexin, targeting integrin αvβ6 has been developed with better affinity and selectivity than previous probes. Clinical data supports its safety and metabolic stability, and future research will explore its diagnostic and staging value in different types of tumors, providing a new and precise evaluation method for malignant tumors.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a new type of PET scan that uses a molecule targeting a protein called integrin αvβ6 — a marker found on the surface of certain cancer cells. Researchers want to see if this specialized scan can better detect and characterize tumors (including lung cancer) compared to existing imaging methods. This is a diagnostic imaging study, not a treatment trial. **You may be eligible if...** - You are 18 or older - You have a newly confirmed malignant tumor or suspected lung cancer - You have not yet received any cancer treatment (no chemotherapy, radiation, or targeted therapy before the scan) - Your general health is good (ECOG score 0–1) **You may NOT be eligible if...** - You have a known allergy to the imaging agent - You have severe liver or kidney problems - You are claustrophobic or have a psychiatric disorder - You have had another cancer before this diagnosis - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPET/CT scans

Diagnostic Test: For 68Ga-Trivehexin PET/CT, no special preparation was required. Approximately 50 min after an i.v. administration of \[68Ga\]Ga-Trivehexin with a dose of 1.85-2.22 MBq/kg, and the PET acquisition time was 2.5 min per bed.


Locations(1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, China

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NCT05835570


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