Malignant Neoplasm Clinical Trials

171 recruitingLast updated: June 17, 2026

There are 171 actively recruiting malignant neoplasm clinical trials across 49 countries. Studies span Phase 2, Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 4. Top locations include Houston, Texas, United States, Los Angeles, California, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Malignant Neoplasm Trials at a Glance

171 actively recruiting trials for malignant neoplasm are listed on ClinicalTrialsFinder across 6 cities in 49 countries. The largest study group is Phase 2 with 53 trials, with the heaviest enrollment activity in Houston, Los Angeles, and New York. Lead sponsors running malignant neoplasm studies include M.D. Anderson Cancer Center, Mayo Clinic, and City of Hope Medical Center.

Browse malignant neoplasm trials by phase

Treatments under study

About Malignant Neoplasm Clinical Trials

Looking for clinical trials for Malignant Neoplasm? There are currently 42 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Malignant Neoplasm trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Malignant Neoplasm clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 171 trials

Recruiting

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

Bladder CancerKidney CancerRenal Cancer+2 more
National Cancer Institute (NCI)5,950 enrolled1 locationNCT00026884
Recruiting
Phase 3

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic140 enrolled4 locationsNCT03750227
Recruiting
Not Applicable

Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer Syndromes

Hereditary Malignant NeoplasmHereditary Neoplastic Syndrome
University of Michigan Rogel Cancer Center625 enrolled1 locationNCT06927947
Recruiting
Phase 2

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Malignant Neoplasm
Merck Sharp & Dohme LLC130 enrolled28 locationsNCT07252739
Recruiting
Phase 2

Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus

Merkel Cell CarcinomaMalignant NeoplasmAcquired Immunodeficiency Syndrome+5 more
M.D. Anderson Cancer Center100 enrolled1 locationNCT02479698
Recruiting
Phase 1Phase 2

A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21)

LymphomaMalignant NeoplasmCarcinoma, Merkel Cell
Merck Sharp & Dohme LLC20 enrolled7 locationsNCT07302347
Recruiting
Phase 1Phase 2

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

Stage IVB Prostate Cancer AJCC v8Metastatic Malignant Neoplasm in the BoneMetastatic Castration-Resistant Prostate Carcinoma+1 more
National Cancer Institute (NCI)90 enrolled32 locationsNCT04071236
Recruiting
Phase 1Phase 2

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+1 more
Kari Kendra24 enrolled1 locationNCT05588453
Recruiting
Phase 1

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

MelanomaNon-small Cell Lung CancerThyroid Cancer+10 more
Pfizer124 enrolled82 locationsNCT05538130
Recruiting
Phase 2

Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy

Muscle-Invasive Bladder CarcinomaMalignant Neoplasm of Bladder
Case Comprehensive Cancer Center40 enrolled1 locationNCT06290687
Recruiting
Not Applicable

Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

Bone PainMetastatic Malignant Neoplasm in the BonePlasma Cell Myeloma
University of Southern California100 enrolled9 locationsNCT03858205
Recruiting
Phase 1

A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)

Malignant Neoplasm
Merck Sharp & Dohme LLC250 enrolled19 locationsNCT07247110
Recruiting
Phase 1

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

Stage III Hepatocellular Carcinoma AJCC v8Stage IV Hepatocellular Carcinoma AJCC v8Refractory Malignant Solid Neoplasm+4 more
University of Southern California36 enrolled2 locationsNCT05791448
Recruiting
Phase 3

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Metastatic Colorectal CarcinomaStage IV Colorectal Cancer AJCC v8Unresectable Colorectal Carcinoma+1 more
ECOG-ACRIN Cancer Research Group408 enrolled60 locationsNCT05863195
Recruiting
Not Applicable

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

Lung CarcinomaStage IIIA Lung Cancer AJCC v8Lung Non-Small Cell Carcinoma+3 more
Northwestern University70 enrolled1 locationNCT05802186
Recruiting
Phase 1

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

Metastatic Breast CancerHER2-negative Breast CancerAdvanced Solid Tumor+6 more
BeOne Medicines399 enrolled63 locationsNCT06120283
Recruiting
Phase 2

Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy

Metastatic Malignant Neoplasm in the LiverLiver and Intrahepatic Bile Duct NeoplasmPrimary Malignant Liver Neoplasm
M.D. Anderson Cancer Center140 enrolled1 locationNCT04982653
Recruiting
Phase 1Phase 2

STereotActic Body Radiotherapy and 177Lutetium PSMA in Locally Advanced Prostate Cancer

Malignant Neoplasm of ProstateLocally Advanced Prostate Cancer
Angela Y. Jia, MD PhD45 enrolled1 locationNCT06574880
Recruiting
Not Applicable

Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery

Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University90 enrolled2 locationsNCT03184038
Recruiting
Phase 1

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909