Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

This study is testing whether a combination of magnesium and vitamin B6 supplements can reduce depressive symptoms in people with a first episode of bipolar I disorder who are already on stable psychiatric medications. The goal is to see if this safe, affordable supplement can serve as an add-on treatment to improve mood. **You may be eligible if...** - You are between 18 and 50 years old - You have been diagnosed with bipolar I disorder within the past 10 years - You have at least two mild depressive symptoms currently - Your manic symptoms are low (YMRS score below 15) - Your psychiatric medications have been stable for at least 2 weeks and are expected to stay unchanged for the 4-week study period **You may NOT be eligible if...** - You have active or severe manic symptoms - You have been diagnosed with schizophrenia, substance use disorder (within the past 2 months), or severe personality disorder - You weigh more than 350 pounds - You have unstable heart, kidney, liver, or neurological disease - You are pregnant or not using an accepted form of contraception Talk to your doctor to see if this trial is right for you.