Coronary Flow During Rapid Heart Rates
Coronary Epicardial and Microcirculatory Determinants of Ventricular Tachycardia Tolerability
Imperial College London
70 participants
Aug 1, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT? Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.
Eligibility
Inclusion Criteria3
- Able to give valid consent
- Referred for coronary angiography or coronary angioplasty
- Suitable for percutaneous physiological interrogation and PCI when clinically indicated
Exclusion Criteria6
- Unable to give valid consent
- Pregnant or breastfeeding women
- Unstable coronary artery disease (acute coronary syndrome)
- Severe multivessel coronary artery disease suitable for coronary artery bypass grafting
- Severe heart valve disease
- Severe (NYHA IV) heart failure
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Participants undergoing coronary angiography will have measurements of blood pressure, coronary pressure and coronary flow during simulated VT. VT will be simulated using pacing at a range of heart rates.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05841199