Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.
Steno Diabetes Center Copenhagen
8 participants
Jan 1, 2026
INTERVENTIONAL
Conditions
Summary
The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.
Eligibility
Inclusion Criteria1
- subjects with NAFLD (liver fat content ≥5% liver fat content verified on MRS in the screening NAFLD study)
Exclusion Criteria7
- BMI<18.5 and BMI>30 kg/m2
- Family history of diabetes (siblings, parent, and grandparents)
- Disease/medication known to affect primary outcome
- Self-reported high physical activity level
- Alcohol intake above general recommendations.
- Metabolic/liver disease
- Weight gain/loss of >3 kg within the past 6 months
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Interventions
The intervention consist of 4-weeks low calories diet (LCD) using total meal replacement from NUPO. A dietician will guide the participants an ensure well-being during the intervention.
No intervention
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05842850