RecruitingNot ApplicableNCT05842850

Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals

Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.

Sponsor

Steno Diabetes Center Copenhagen

Enrollment

8 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

NAFLD

Summary

The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.

Eligibility

Min Age: 35 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Caloric restriction intervention and No intervention for people with nafld. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 35 Years to 40 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALCaloric restriction intervention

The intervention consist of 4-weeks low calories diet (LCD) using total meal replacement from NUPO. A dietician will guide the participants an ensure well-being during the intervention.

OTHERNo intervention

No intervention