Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD

This study compares two exercise programs — moderate-intensity outdoor walking (4 sessions per week, 60 minutes each) and high-intensity interval training (HIIT, 3 sessions per week, 50 minutes each) — combined with a low glycaemic index Mediterranean diet, versus diet alone, in adults aged 18–65 with obesity and non-alcoholic fatty liver disease (NAFLD). Researchers are primarily looking at whether these exercise-plus-diet programs reduce inflammation markers in the body, and secondarily whether they improve body composition, physical fitness, gut microbiome, and quality of life over 4 months. Adults with a BMI of 30 or above (or significant abdominal obesity) and ultrasound-confirmed liver fat accumulation are eligible; those with other significant liver, neurological, cardiovascular, or musculoskeletal conditions that would prevent exercise are excluded. Participation involves attending supervised exercise sessions and following a structured dietary plan with guidance from specialized staff. This summary was prepared as patient-facing educational content using AI assistance.