RecruitingPhase 2NCT05848258

An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis

An Adaptive Phase 2a/2b, Randomized, Double-Blind, Placebo-Controlled Study of LY3871801 in Adult Participants With Moderately-to-Severely Active Rheumatoid Arthritis

Sponsor

Eli Lilly and Company

Enrollment

380 participants

Start Date

May 23, 2023

Study Type

INTERVENTIONAL

Conditions

Rheumatoid Arthritis

Summary

The main purpose of this study is to evaluate the efficacy and safety of LY3871801 in adult participants with active moderately-to-severe rheumatoid arthritis (RA).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called LY3871801 for people with moderate to severe rheumatoid arthritis (RA) — a condition where the immune system attacks the joints, causing pain, swelling, and stiffness. The drug targets a specific immune pathway to reduce inflammation. **You may be eligible if...** - You are 18 or older - You have had a confirmed RA diagnosis for at least 3 months - You have moderate to severe active RA, with at least 6 swollen joints and 6 tender joints - Previous RA medications (like methotrexate or biologics) have not worked well enough for you **You may NOT be eligible if...** - You have active or chronic infections, including tuberculosis or hepatitis - You have serious heart, liver, or kidney disease - You are pregnant or planning to become pregnant - You have received certain immune-suppressing therapies recently - You have a history of blood clots or stroke Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGLY3871801

Administered orally

DRUGPlacebo

Administered orally

Locations(57)

Newport Huntington Medical Group

Huntington Beach, California, United States

Integrity Clinical Research

Doral, Florida, United States

Advanced Clinical Research of Orlando - Ocoee

Ocoee, Florida, United States

Encore Medical Research - Weston

Weston, Florida, United States

Conquest Research

Winter Park, Florida, United States

Willow Rheumatology and Wellness PLLC

Willowbrook, Illinois, United States

Accurate Clinical Research, Inc

Lake Charles, Louisiana, United States

Joseph S. and Diane H. Steinberg Ambulatory Care Center

Brooklyn, New York, United States

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Accellacare - Salisbury

Salisbury, North Carolina, United States

Accurate Clinical Research, Inc

Houston, Texas, United States

Overlake Arthritis and Osteoporosis Center

Bellevue, Washington, United States

CIPREC

Buenos Aires, Argentina

Mautalen Salud e Investigación

Buenos Aires, Argentina

CENUDIAB

Buenos Aires, Argentina

Medicina Reumatológica

San Fernando, Argentina

Instituto de Alta Complejidad San Isidro

San Isidro, Argentina

Medical Plus

Uherské Hradiště, Czechia

CHD Vendee

La Roche-sur-Yon, France

CHU Montpellier Lapeyronie Hospital

Montpellier, France

CHU de Nice

Nice, France

Centre Hospitalier Regional D'Orleans

Orléans, France

Hopitaux Universitaires Paris Centre-Hopital Cochin

Paris, France

Centre Hospitalier Universitaire de Reims - l'Hôpital Maison Blanche

Reims, France

CHU Strasbourg-Hautepierre

Strasbourg, France

Universitaetsklinikum Koeln

Cologne, Germany

HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T

Hamburg, Germany

Revita Clinic

Budapest, Hungary

Clinexpert Kft.

Budapest, Hungary

Óbudai Egészségügyi Centrum

Budapest, Hungary

CRU Hungary Kft.

Encs, Hungary

Vásárhelyi Sárkányfű KFT

Hódmezővásárhely, Hungary

Kistarcsai Flor Ferenc Korhaz

Kistarcsa, Hungary

Regia Med Kft

Székesfehérvár, Hungary

Vital Medical Center

Veszprém, Hungary

Avron Hospitals

Ahmedabad, India

Sushruta Multispeciality Hospital & Research Centre

Hubli, India

Government Medical College And Hospital - Nagpur

Nagpur, India

All India Institute of Medical Sciences (AIIMS) - Nagpur

Nagpur, India

Grant Medical Foundation - Ruby Hall Clinic

Pune, India

Medipoint Hospitals Pvt. Ltd.

Pune, India

All India Institute of Medical Sciences

Raipur, India

Investigacion y Biomedicina de Chihuahua

Chihuahua City, Mexico

Hospital Aranda de La Parra

León, Mexico

Biológicos Especializados

Mexico City, Mexico

Kohler and Milstein Research S.A. de C.V.

Mérida, Mexico

Medical Care and Research SA de CV

Mérida, Mexico

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

Monterrey, Mexico

Cicmex Centro de Investigación Clínica de México

Morelia, Mexico

Centro de Atención e Investigación Cardiovascular del Potosí

San Luis Potosí City, Mexico

CIMAB SA de CV

Torreón, Mexico

Nova Reuma Domyslawska i Rusilowicz Spolka Partnerska Lekarza Reumatologa i Fizjoterapeuty

Bialystok, Poland

Nzoz Bif-Med

Bytom, Poland

MICS Centrum Medyczne Warszawa

Warsaw, Poland

Centrum Medyczne Reuma Park

Warsaw, Poland

Hull Royal Infirmary

Hull, United Kingdom

New Cross Hospital

Wolverhampton, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05848258

Related Trials

An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis

NCT0702955514 locations

A Study of AZD0120 in Autoimmune Diseases

NCT0729584718 locations

dEtection of rheumAtoid aRthritis - Interstitial Lung dIseasE by Thoracic ultRasound

NCT062356451 location

Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease

NCT032977751 location

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

NCT052770251 location