buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest
buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest (RESTORE)
University of California, San Francisco
30 participants
Aug 7, 2023
INTERVENTIONAL
Conditions
Summary
RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.
Eligibility
Inclusion Criteria7
- Age ≥18 years old
- Non-traumatic, out-of-hospital cardiac arrest
- Comatose on admission - defined as not following commands
- Return of spontaneous circulation (ROSC) within less than 45 minutes
- Admission to the intensive care unit
- Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous
- EEG monitoring within 7 days from ROSC
Exclusion Criteria3
- Acute cerebral hemorrhage or infarction
- Pregnancy
- Prisoners
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Interventions
The objective of the burst suppression EEG target is to stop seizures by titrating the anesthetic infusion to suppress most of the EEG background (\>50% suppressed/attenuated). After this 24-hour period, this target would be continued for 24 hours. The anesthetic will then be tapered under EEG monitoring. In case of PCARSE recurrence, the intervention with the same target will be re-initiated for another cycle of 24 hours.
is to stop seizures by titrating the anesthetic infusion without suppressing most of the EEG background. This target would be continued for 24 hours. After this 24-hours period, this target would be continued for 24 hours. The anesthetic will then be tapered under EEG monitoring. In case of PCARSE recurrence, the intervention with the same target will be re-initiated for another cycle of 24 hours.
Locations(1)
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NCT05851391