RecruitingNCT05857150

Exercise Response in Humans With Obesity

Sponsor

Mayo Clinic

Enrollment

120 participants

Start Date

Sep 22, 2023

Study Type

OBSERVATIONAL

Conditions

Obese

Summary

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Eligibility

Min Age: 20 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Dual-Energy X-Ray Absorptiometry, a procedure called Fat Biopsy, and others for people with obese. The study is currently recruiting participants at 1 location. People eligible for this study include aged 20 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTTreadmill Test

Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).

DIAGNOSTIC_TESTStrength Test

Measure the strength of leg muscles by kicking against a machine with resistance.

DIAGNOSTIC_TESTDual-Energy X-Ray Absorptiometry

Body composition measurement.

PROCEDUREMuscle Biopsy

Obtain a small piece of muscles from the upper part of the legs

PROCEDUREFat Biopsy

Fat sample taken from abdomen

DIAGNOSTIC_TESTResting Energy Expenditure

Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.

DIAGNOSTIC_TESTMagnetic resonance imaging

MRI on upper leg to look at fat and muscle