Imaging Features for the Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis
Imaging Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis (IRRAS-BM)
Asan Medical Center
132 participants
Dec 7, 2023
OBSERVATIONAL
Conditions
Summary
This trial uses multi-parametric magnetic resonance imaging (MRI) to develop and validate imaging risk score to predict radiation necrosis in participants with brain metastasis treated with radiation therapy. Diagnostic procedures, such as multi-parametric magnetic resonance imaging (MRI), may improve the ability to diagnose radiation necrosis early and help establish treatment strategies.
Eligibility
Inclusion Criteria9
- Patients who underwent stereotactic radiosurgery (SRS, gamma-knife radiosurgery or cyberknife radiosurgery) for brain metastases
- Patients with lesions eligible for SRS :
- One to ten newly diagnosed brain metastases
- Patients without acute neurological symptom
- Patients with a Karnofsky performance status score of 70 or higher
- Patients who underwent brain MRI within 1 month of enrollment
- Patients with measurable enhancing lesions on MRI.
- Patients who have available reference standard (second-look surgery for recurrence) or available follow up imaging for clinic-radiologic reference standard.
- A longest diameter \> 1.5 cm for tumor habitat analysis.
Exclusion Criteria5
- Patients who have undergone prior brain surgery, SRS, or whole-brain radiation therapy.
- Patients who are diagnosed with leukemia, lymphoma, germ-cell tumor, small-cell lung cancer, leptomeningeal disease, or unknown primary tumor.
- Patients with age \< 18 years.
- Patients without baseline MRI.
- Patients with nonmeasurable enhancing lesions on MRI : all other lesions, including lesions with longest dimension \< 10 mm, lesions with borders that cannot be reproducibly measured, dural metastases, bony skull metastases, and leptomeningeal disease.
Interventions
Pre-and post-contrast enhanced T1-weighted image, T2-weighted image, fluid-attenuated inversion recovery image
Diffusion-weighted MRI
Cerebral blood flow imaging parameter
Cerebral blood volume and vessel architectural imaging parameters
Locations(1)
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NCT05868928