Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

This study tests whether a digital therapeutic app (a structured brain-training program) can reduce apathy — a common symptom in older adults with late-life depression that makes it hard to feel motivated or interested in daily activities. The study uses brain scans (MRI) to understand how the treatment affects brain networks. **You may be eligible if...** - You are 60 years or older - You have a diagnosis of major depressive disorder (without psychotic features) - You are experiencing significant apathy (lack of motivation or interest) along with depression - Your depression score on a standard scale is 16 or above - You are not on antidepressants or have been on a stable dose for at least 8 weeks - You have access to a computer or tablet with Wi-Fi - You can safely have an MRI **You may NOT be eligible if...** - You have another psychiatric diagnosis such as bipolar disorder, psychosis, or PTSD - You have a history of stroke, dementia, Parkinson's disease, or other brain conditions - You are at risk for suicide or have attempted suicide in the past year - You have had electroconvulsive therapy in the past year - You have had a substance use disorder in the past 6 months - You have claustrophobia or cannot safely have an MRI Talk to your doctor to see if this trial is right for you.