RecruitingPhase 2NCT05879250

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

A Multi-Arm, Open Label, Phase II Trial of WP1066 and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Sponsor

Northwestern University

Enrollment

39 participants

Start Date

May 22, 2024

Study Type

INTERVENTIONAL

Conditions

Glioblastoma, IDH-wildtype MGMT-Unmethylated Glioblastoma

Summary

This phase II trial tests how well the combination of WP1066 and radiation therapy works in treating newly diagnosed glioblastoma. Glioblastoma is difficult to treat effectively because the cells within the tumor vary widely and are controlled by factors within and around the tumor, requiring multiple approaches to treat the tumor. The study drug WP1066 targets a specific pathway, known as STAT3, which is responsible for promoting tumor growth and causing the body's immune system to avoid attacking the tumor. Radiation therapy prevents glioblastoma from growing. Giving WP1066 with radiation therapy may prevent glioblastoma from growing and prolong survival.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests WP1066 — a new investigational drug that targets a protein called STAT3 — combined with radiation therapy, in patients who have been newly diagnosed with glioblastoma (a very aggressive type of brain cancer). The study looks at safety and how well the treatment works. **You may be eligible if...** - You have been newly diagnosed with glioblastoma (IDH wild-type, confirmed by pathology) - Your cancer has tested MGMT-unmethylated - You are 18 or older and in good enough health (Karnofsky score of 60% or above) - You had your brain surgery (biopsy or resection) within the past 8 weeks - Your blood counts, liver, and kidney function are within acceptable ranges **You may NOT be eligible if...** - You have received a gene therapy, bevacizumab, or Gliadel wafer at any time - You have had a symptomatic brain hemorrhage - You have uncontrolled seizures - Your brain tumor is very large or causing significant brain shift - You are HIV-positive and on antiretroviral therapy - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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